Survey and monitoring of opium poppy and wheat in Afghanistan: 2003-2009

An integrated application of remote-sensing technology was devised and applied in Afghanistan during 2003–2009 providing critical information on cereal and poppy cultivation and poppy eradication. The results influenced UK and international policy and counter-narcotics actions in Afghanistan

The 1.23 Ga Fjellhovdane rhyolite, Grøssæ-Totak; a new age within the Telemark supracrustals, southern Norway

The Grøssæ-Totak supracrustal belt is part of the several-kilometre thick Telemark supracrustal sequences that are exposed in southern Norway. Deposition of the Telemark supracrustals spans the period between Telemarkian continental growth at ~1.52-1.48 Ga and Sveconorwegian orogenesis associated with continental collision at ~1.1-0.9 Ga. The timing of deposition is largely constrained by U-Pb geochronology of detrital zircons in sedimentary units, and igneous zircons within felsic volcanics. A younger Supergroup that has been referred to as the Sveconorwegian Supergroup comprises depositional ages younger than 1.16 Ga; units of the Grøssae-Totak belt have been mapped as part of this Supergroup. This study presents a new U-Pb age of 1233 ± 29 Ma for the Fjellhovdane rhyolite, one of the lowermost units within the Grøssæ-Totak belt; this age suggests that at least the lower part of this sequence is not part of the Sveconorwegian Supergroup, but formed in an earlier volcano-sedimentary basin that is correlative in age to the Sæsvatn-Valldal and Setesdal supracrustal belts that occur to the west and south respectively. The geochemistry of the Fjellhovdane rhyolite is compatible with crustal melting of previously-formed supra-subduction rocks, as has been advocated for the Sæsvatn-Valldal rhyolites

The application of remote sensing to identify and measure sealed soil and vegetated surfaces in urban environments

Soil is an important non-renewable source. Its protection and allocation is critical to sustainable development goals. Urban development presents an important drive of soil loss due to sealing over by buildings, pavements and transport infrastructure. Monitoring sealed soil surfaces in urban environments is gaining increasing interest not only for scientific research studies but also for local planning and national authorities. The aim of this research was to investigate the extent to which automated classification methods can detect soil sealing in UK urban environments, by remote sensing. The objectives include development of object-based classification methods, using two types of earth observation data, and evaluation by comparison with manual aerial photo interpretation techniques. Four sample areas within the city of Cambridge were used for the development of an object-based classification model. The acquired data was a true-colour aerial photography (0.125 m resolution) and a QuickBird satellite imagery (2.8 multi-spectral resolution). The classification scheme included the following land cover classes: sealed surfaces, vegetated surfaces, trees, bare soil and rail tracks. Shadowed areas were also identified as an initial class and attempts were made to reclassify them into the actual land cover type. The accuracy of the thematic maps was determined by comparison with polygons derived from manual air-photo interpretation; the average overall accuracy was 84%. The creation of simple binary maps of sealed vs. vegetated surfaces resulted in a statistically significant accuracy increase to 92%. The integration of ancillary data (OS MasterMap) into the object-based model did not improve the performance of the model (overall accuracy of 91%). The use of satellite data in the object-based model gave an overall accuracy of 80%, a 7% decrease compared to the aerial photography. Future investigation will explore whether the integration of elevation data will aid to discriminate features such as trees from other vegetation types. The use of colour infrared aerial photography should also be tested. Finally, the application of the object- based classification model into a different study area would test its transferability.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The application of remote sensing to identify and measure sealed soil and vegetated surfaces in urban environments

Soil is an important non-renewable source. Its protection and allocation is critical to sustainable development goals. Urban development presents an important drive of soil loss due to sealing over by buildings, pavements and transport infrastructure. Monitoring sealed soil surfaces in urban environments is gaining increasing interest not only for scientific research studies but also for local planning and national authorities. The aim of this research was to investigate the extent to which automated classification methods can detect soil sealing in UK urban environments, by remote sensing. The objectives include development of object-based classification methods, using two types of earth observation data, and evaluation by comparison with manual aerial photo interpretation techniques. Four sample areas within the city of Cambridge were used for the development of an object-based classification model. The acquired data was a true-colour aerial photography (0.125 m resolution) and a QuickBird satellite imagery (2.8 multi-spectral resolution). The classification scheme included the following land cover classes: sealed surfaces, vegetated surfaces, trees, bare soil and rail tracks. Shadowed areas were also identified as an initial class and attempts were made to reclassify them into the actual land cover type. The accuracy of the thematic maps was determined by comparison with polygons derived from manual air-photo interpretation; the average overall accuracy was 84%. The creation of simple binary maps of sealed vs. vegetated surfaces resulted in a statistically significant accuracy increase to 92%. The integration of ancillary data (OS MasterMap) into the object-based model did not improve the performance of the model (overall accuracy of 91%). The use of satellite data in the object-based model gave an overall accuracy of 80%, a 7% decrease compared to the aerial photography. Future investigation will explore whether the integration of elevation data will aid to discriminate features such as trees from other vegetation types. The use of colour infrared aerial photography should also be tested. Finally, the application of the object- based classification model into a different study area would test its transferability.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Reconstructions of biomass burning from sediment charcoal records to improve data-model comparisons

The location, timing, spatial extent, and frequency of wildfires are changing rapidly in many parts of the world, producing substantial impacts on ecosystems, people, and potentially climate. Paleofire records based on charcoal accumulation in sediments enable modern changes in biomass burning to be considered in their long-term context. Paleofire records also provide insights into the causes and impacts of past wildfires and emissions when analyzed in conjunction with other paleoenvironmental data and with fire models. Here we present new 1000 year and 22 000 year trends and gridded biomass burning reconstructions based on the Global Charcoal Database version 3, which includes 736 charcoal records (57 more than in version 2). The new gridded reconstructions reveal the spatial patterns underlying the temporal trends in the data, allowing insights into likely controls on biomass burning at regional to global scales. In the most recent few decades, biomass burning has sharply increased in both hemispheres, but especially in the north, where charcoal fluxes are now higher than at any other time during the past 22 000 {years}. We also discuss methodological issues relevant to data-model comparisons, and identify areas for future research. Spatially gridded versions of the global dataset from GCDv3 are provided to facilitate comparison with and validation of global fire simulations

Progress report no. 1

Statement of responsibility on title-page reads: Editors: I.A. Forbes, M.J. Driscoll, D.D. Lanning, I. Kaplan, N.C. Rasmussen; Contributors: S.A. Ali, S.T. Brewer, D.K. Choi, F.M. Clikeman, W.R. Corcoran, M.J. Driscoll, I.A. Forbes, C.W. Forsberg, S.L. Ho, C.S. Kang, I. Kaplan, J.L. Klucar, D.D. Lanning, T.C. Leung, E.L. McFarland P.G. Mertens, N.R. Ortiz, A. Pant, N.A. Passman, N.C. Rasmussen, M.K. Sheaffer, D.A. Shupe, G.E. Sullivan, A.T. Supple, J.W. Synan, C.P. Tzanos, W.J. Westlake"MIT-4105-3."Includes bibliographical referencesProgress report; June 30, 1970U.S. Atomic Energy Commission contracts: AT(30-1)410

A Social Identity Approach to Sport Psychology: Principles, Practice, and Prospects.

Drawing on social identity theory and self-categorization theory, we outline an approach to sport psychology that understands groups not simply as features of sporting contexts but rather as elements that can be, and often are, incorporated into a person's sense of self and, through this, become powerful determinants of their sport-related behavior. The underpinnings of this social identity approach are outlined, and four key lessons for sport that are indicative of the analytical and practical power of the approach are presented. These suggest that social identity is the basis for sports group (1) behavior, (2) formation and development, (3) support and stress appraisal, and (4) leadership. Building on recent developments within sport science, we outline an agenda for future research by identifying a range of topics to which the social identity approach could fruitfully contribute

A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.

Funder: Victorian Cancer AgencyFunder: NIHR Manchester Biomedical Research CentreFunder: Cancer Research UKFunder: Cancer Council TasmaniaFunder: Instituto de Salud Carlos IIIFunder: Cancer AustraliaFunder: NIHR Oxford Biomedical Research CentreFunder: Fundación Científica de la Asociación Española Contra el CáncerFunder: Cancer Council South AustraliaFunder: Swedish Cancer SocietyFunder: NIHR Cambridge Biomedical Research CentreFunder: Institut Català de la SalutFunder: Cancer Council VictoriaFunder: Prostate Cancer Foundation of AustraliaFunder: National Institutes of HealthBACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospectively assessing prostate-specific antigen (PSA) screening in men with germline mismatch repair pathogenic variants. Here, we report the usefulness of PSA screening, prostate cancer incidence, and tumour characteristics after the first screening round in men with and without these germline pathogenic variants. METHODS: The IMPACT study is an international, prospective study. Men aged 40-69 years without a previous prostate cancer diagnosis and with a known germline pathogenic variant in the MLH1, MSH2, or MSH6 gene, and age-matched male controls who tested negative for a familial pathogenic variant in these genes were recruited from 34 genetic and urology clinics in eight countries, and underwent a baseline PSA screening. Men who had a PSA level higher than 3·0 ng/mL were offered a transrectal, ultrasound-guided, prostate biopsy and a histopathological analysis was done. All participants are undergoing a minimum of 5 years' annual screening. The primary endpoint was to determine the incidence, stage, and pathology of screening-detected prostate cancer in carriers of pathogenic variants compared with non-carrier controls. We used Fisher's exact test to compare the number of cases, cancer incidence, and positive predictive values of the PSA cutoff and biopsy between carriers and non-carriers and the differences between disease types (ie, cancer vs no cancer, clinically significant cancer vs no cancer). We assessed screening outcomes and tumour characteristics by pathogenic variant status. Here we present results from the first round of PSA screening in the IMPACT study. This study is registered with ClinicalTrials.gov, NCT00261456, and is now closed to accrual. FINDINGS: Between Sept 28, 2012, and March 1, 2020, 828 men were recruited (644 carriers of mismatch repair pathogenic variants [204 carriers of MLH1, 305 carriers of MSH2, and 135 carriers of MSH6] and 184 non-carrier controls [65 non-carriers of MLH1, 76 non-carriers of MSH2, and 43 non-carriers of MSH6]), and in order to boost the sample size for the non-carrier control groups, we randomly selected 134 non-carriers from the BRCA1 and BRCA2 cohort of the IMPACT study, who were included in all three non-carrier cohorts. Men were predominantly of European ancestry (899 [93%] of 953 with available data), with a mean age of 52·8 years (SD 8·3). Within the first screening round, 56 (6%) men had a PSA concentration of more than 3·0 ng/mL and 35 (4%) biopsies were done. The overall incidence of prostate cancer was 1·9% (18 of 962; 95% CI 1·1-2·9). The incidence among MSH2 carriers was 4·3% (13 of 305; 95% CI 2·3-7·2), MSH2 non-carrier controls was 0·5% (one of 210; 0·0-2·6), MSH6 carriers was 3·0% (four of 135; 0·8-7·4), and none were detected among the MLH1 carriers, MLH1 non-carrier controls, and MSH6 non-carrier controls. Prostate cancer incidence, using a PSA threshold of higher than 3·0 ng/mL, was higher in MSH2 carriers than in MSH2 non-carrier controls (4·3% vs 0·5%; p=0·011) and MSH6 carriers than MSH6 non-carrier controls (3·0% vs 0%; p=0·034). The overall positive predictive value of biopsy using a PSA threshold of 3·0 ng/mL was 51·4% (95% CI 34·0-68·6), and the overall positive predictive value of a PSA threshold of 3·0 ng/mL was 32·1% (20·3-46·0). INTERPRETATION: After the first screening round, carriers of MSH2 and MSH6 pathogenic variants had a higher incidence of prostate cancer compared with age-matched non-carrier controls. These findings support the use of targeted PSA screening in these men to identify those with clinically significant prostate cancer. Further annual screening rounds will need to confirm these findings. FUNDING: Cancer Research UK, The Ronald and Rita McAulay Foundation, the National Institute for Health Research support to Biomedical Research Centres (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; Oxford; Manchester and the Cambridge Clinical Research Centre), Mr and Mrs Jack Baker, the Cancer Council of Tasmania, Cancer Australia, Prostate Cancer Foundation of Australia, Cancer Council of Victoria, Cancer Council of South Australia, the Victorian Cancer Agency, Cancer Australia, Prostate Cancer Foundation of Australia, Asociación Española Contra el Cáncer (AECC), the Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER), the Institut Català de la Salut, Autonomous Government of Catalonia, Fundação para a Ciência e a Tecnologia, National Institutes of Health National Cancer Institute, Swedish Cancer Society, General Hospital in Malmö Foundation for Combating Cancer

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work in morphologically normal tissue were also at work in cancer. Our observations demonstrate the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis. This mechanism gives rise to extensive branching evolution and cancer clone mixing, as exemplified by the coexistence of multiple cancer lineages harboring distinct ERG fusions within a single cancer nodule. Subsets of mutations were shared either by morphologically normal and malignant tissues or between different ERG lineages, indicating earlier or separate clonal cell expansions. Our observations inform on the origin of multifocal disease and have implications for prostate cancer therapy in individual cases